ApoE Status Report
Overview
- The APOE Status Report is a targeted genetic assessment that determines an individual's Apolipoprotein E (APOE) genotype using the two clinically validated genetic variants (rs429358 and rs7412) that define the three major APOE isoforms: ε2, ε3, and ε4.
- APOE plays a critical role in cholesterol transport, lipid metabolism, neuroinflammation, and amyloid-β processing. Genetic variation within APOE has been associated with differences in susceptibility to late-onset Alzheimer's disease, cardiovascular health, and long-term cognitive aging.
- By providing precise APOE genotyping, this report helps healthcare professionals identify genetic risk patterns, support personalized preventive strategies, and guide long-term brain and cardiometabolic health management.
What This Test Covers
APOE Genotype Analysis
Determines the individual's APOE genotype based on the two defining SNPs
- rs429358
- rs7412
These variants identify the three major APOE isoforms:
- APOE ε2
- APOE ε3
- APOE ε4
APOE Status & Risk Interpretation
Provides a clear genetic risk classification based on APOE genotype
- Lower Risk
- Medium Risk
- Higher Risk
This interpretation supports provider-led risk assessment and preventive care planning.
Comprehensive APOE Genotype Interpretation
Includes a detailed interpretation table outlining
- APOE genotype
- Allelic composition
- APOE isoform(s)
- Associated risk category
- Clinical interpretation
Personalized Brain Health Support
The report provides evidence-informed recommendations across
- Nutrition - Dietary strategies that support brain health and lipid metabolism
- Lifestyle - Daily habits that promote cognitive resilience and healthy aging
- Cognitive Exercise - Brain-training strategies to support memory and neural function
- Brain Health - Educational insights into long-term cognitive wellness
Why It Matters
APOE is one of the most extensively studied genetic markers associated with cognitive aging and lipid metabolism. While genotype alone does not determine whether disease will occur, it can provide valuable insight into inherited biological susceptibility.
Understanding APOE status enables healthcare professionals to identify individuals who may benefit from earlier monitoring, personalized preventive interventions, and targeted lifestyle strategies that support long-term brain and cardiometabolic health.
Rather than waiting for symptoms to emerge, clinicians can use APOE status to deliver more proactive, precision-guided care.
Who Should Take This Test
The APOE Status Report is designed for
Physicians and neurologists
Functional & integrative medicine practitioners
Preventive and longevity-focused clinicians
Cardiovascular specialists
Healthcare professionals supporting patients with cognitive concerns or a family history of Alzheimer's disease
What You’ll Receive
Comprehensive Report
A clean report layout with with APOE genotype determination (ε2, ε3, ε4), APOE status and genetic risk interpretation, and a comprehensive genotype interpretation table.
Personalized Insights
Personalized nutrition insights, lifestyle recommendations, cognitive exercise training guidance, and brain health education.
Provider Portal Access
Secure digital report access via the ExtendingME Provider Portal for seamless report viewing and sharing.
SNP-Specific Risk Interpretations
For providers seeking deeper genetic insights, we offer detailed SNP-level interpretations.
- Genetic marker identification (e.g., gene name, rsID)
- Patient genotype results and what it means for your patient's health
- Scientific explanation of how these genes influence specific health traits
Turnaround Time
Results are available within 2 weeks from sample receipt and are securely delivered through the Provider Portal for convenient clinical review and patient follow-up.
Collection Method
ExtendingME kits include everything required for convenient, non-invasive saliva collection. Samples can be collected from home and returned for laboratory analysis, providing a simple and accessible approach to genetic testing.
Meet EMma Soft —
Powering Personalized Medicine
EMma Soft is ExtendingME’s proprietary platform designed to connect every part of your personalized medicine offering—from genetic insights to patient engagement and ongoing care. It brings your entire ecosystem together to support scalable growth and long-term value.
