Methylation Panel & Report
Overview
- Methylation is one of the body's most essential biochemical processes, influencing nearly every cell and organ system. It plays a critical role in regulating gene expression, DNA repair, detoxification, neurotransmitter production, cardiovascular health, energy metabolism, antioxidant defense, and healthy aging.
- The Methylation Panel analyzes 40+ clinically relevant genetic variants (SNPs) using an advanced Polygenic Risk Score (PRS) algorithm to evaluate how inherited genetics may influence methylation efficiency and the interconnected metabolic pathways that support optimal health.
- Rather than focusing on a single gene, this comprehensive assessment examines multiple pathways involved in methyl donor generation, folate metabolism, homocysteine recycling, glutathione production, neurotransmitter synthesis, and nutrient utilization, providing a more complete understanding of an individual's methylation capacity.
What Does the Methylation Panel Assess?
The panel evaluates genetic influences across five interconnected biological pathways
Methionine Cycle & Methylation Capacity
Assesses the body's ability to generate, transfer, and recycle methyl groups required for DNA methylation, neurotransmitter synthesis, phospholipid production, and cellular function. It evaluates genetic tendencies affecting
- Homocysteine metabolism
- Choline availability
- Betaine metabolism
- Dimethylglycine production
Folate Cycle & One-Carbon Pool Integration
Evaluates how efficiently folate, vitamin B12, and amino acid metabolism supply one-carbon units required for healthy methylation reactions. Traits assessed include
- Serine metabolism
- Vitamin B12 utilization
- Folate metabolism
Transsulfuration & Redox Pathway
Examines the body's ability to convert homocysteine into glutathione and other sulfur-containing compounds essential for antioxidant defense, detoxification, and cellular protection. Traits assessed include
- High Cysteine Glutathione Disulfide Levels
BH4-Dependent Cofactor & Methylation Interactions
Evaluates genetic factors involved in tetrahydrobiopterin (BH4) metabolism, a critical cofactor required for neurotransmitter production, nitric oxide synthesis, and neurological health. Traits assessed include
- High Phenylalanine Levels
Urea Cycle Function
Assesses genetic influences involved in nitrogen metabolism and metabolic waste clearance, supporting efficient cellular function and overall metabolic balance. Traits assessed include
- High Creatinine Levels
Why Methylation Matters
Methylation influences numerous physiological systems throughout the body.
Variations in genes involved in these pathways may affect
- DNA methylation and gene regulation
- Neurotransmitter synthesis and cognitive function
- Homocysteine metabolism
- Folate and vitamin B12 utilization
- Detoxification capacity
- Glutathione production and antioxidant defense
- Cardiovascular health
- Cellular repair and healthy aging
- Energy metabolism
- Liver function and nutrient metabolism
Understanding these inherited tendencies enables healthcare professionals to personalize nutrition, supplementation, lifestyle interventions, and laboratory monitoring to better support long-term health.
Who Should Take This Test
The Methylation Panel is ideal for individuals who want to optimize their health through personalized genetic insights.
It is particularly beneficial for
Individuals interested in preventive and personalized healthcare.
Those with concerns about cardiovascular, cognitive, or metabolic health.
Individuals looking to optimize energy, mood, and brain function.
People seeking to improve nutrient metabolism and detoxification.
Those interested in healthy aging and long-term wellness.
Healthcare professionals using genetics to personalize nutrition and lifestyle interventions.
What You’ll Receive
Comprehensive Genetic Report
A clean report layout with category, subcategory, and SNP-wise interpretation (based on provider or client preference).
Personalized Insights
Actionable insights for nutrition, lifestyle, supplementation, and additional labs to consider to support metabolic health and long term health.
Provider Portal Access
Secure digital access via the ExtendingME Provider Portal for seamless report viewing and sharing.
SNP-Specific Risk Interpretations
For providers seeking deeper genetic insights, we offer detailed SNP-level interpretations.
- Genetic marker identification (e.g., gene name, rsID)
- Patient genotype results and what it means for your patient's health
- Scientific explanation of how these genes influence specific health traits
Turnaround Time
Results will be available approximately 2 to 3 weeks from the receipt of the sample and will be securely delivered through the Provider Portal, enabling seamless access, viewing, and sharing of reports.
Collection Method
ExtendingME test uses a non-invasive, at-home saliva collection kit, eliminating the need for laboratory visits and enabling seamless integration into clinical workflows.
Unlock the Power of Precision Methylation
ExtendingME's Methylation Panel decodes the genetic blueprint of one of the body's most essential biochemical processes, empowering healthcare professionals with actionable insights to deliver personalized nutrition, targeted lifestyle interventions, and precision-driven care for optimal health and long-term wellness.
Meet EMma Soft —
Powering Personalized Medicine
EMma Soft is ExtendingME’s proprietary platform designed to connect every part of your personalized medicine offering—from genetic insights to patient engagement and ongoing care. It brings your entire ecosystem together to support scalable growth and long-term value.
